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FIGURE 1 Endogenous Estrogens Estrogens are not only involved in gender-specific processes such as development and maintenance of the female phenotype, germ cell maturation, and pregnancy (Yasar et al., 2017)

Tsai G., Yang P., Chung LC., Lange N., Coyle JT

Every week, patients ask me a version of the same question

AA: Arachidonic acid

They exhibited increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy

Looking ahead, improving tissue- or cell-specific vector targeting, building high-throughput screening platforms for FAD-sensitive variants, and using patient-derived iPSC neurons for personalized preclinical testing will be pivotal in transitioning from experimental use to clinical implementation of integrated nutrient plus gene-editing therapies